Game Overview
Dive into a microscopic alien world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that’s easy to pick up but hard to master. Research permanent upgrades to survive 70 different microbes across 8 game modes, each with multiple ascension levels (“depths”).
Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
- Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
- Bomb + Bomb doubles down on explosive power to make Bazooka!
- Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!
- 49 Turrets with unique strengths and functions
- 96 Perks to mix and match that drastically change how you play
- 72 Turret & Weapon Mods that can turn shots into sticky mines or bouncing fireballs
- 32 Mutations that alter the challenges you face each run
- 20-minute Runs that can be continued in Endless Mode
- 60 Bassy Electronic Tunes that adapt to the current mood and intensity
- 100 Steam Achievements
- 49 Cosmetics including spider legs, tank tread and a swarm of drones
- Accessibility Settings for colourblindness and motion sickness
- Cloud Save
- Plays great on Steam Deck! (official Steam Deck Compatibility Review pending)
Genome Guardian is a product of passion – a culmination of everything I love about roguelite shooters, and a novel ‘weapon-combining’ feature that I’ve wanted to realize since I was a teenager. Your support will mean content updates and allow me to make more games in the future.
Installation Instructions
- Click the green button below to be redirected to UploadHaven.com.
- Wait 15 seconds, then click on the “free download” button. Allow the file transfer to complete (note that speeds may be slower with the free plan; upgrading to UploadHaven Pro will increase speeds).
- Once the transfer is complete, right-click the .zip file and select “Extract to Genome Guardian” (To do this you must have 7-Zip, which you can get here).
- Open the folder that you just extracted and run the game as administrator.
- Enjoy the game! If you encounter any missing DLL errors, check the Redist or _CommonRedist folder and install all necessary programs.
Download Links
Download the full version of the game using the links below.
🛠 Easy Setup Guide
- Check for missing DLL files: Navigate to the
_Redistor_CommonRedistfolder in the game directory and install DirectX, Vcredist, and other dependencies. - Use 7-Zip to extract files: If you receive a “file corrupted” error, re-download and extract again.
- Run as Administrator: Right-click the game’s executable file and select “Run as Administrator” to avoid save issues.
💡 Helpful Tips
- Need installation help? Read our full FAQ & Troubleshooting Guide.
- Antivirus False Positives: Temporarily pause your antivirus software during extraction to prevent it from mistakenly blocking game files.
- Update GPU Drivers: For better performance, update your NVIDIA drivers or AMD drivers.
- Game won’t launch? Try compatibility mode or install missing DirectX updates.
- Still getting errors? Some games require updated Visual C++ Redistributables. Download the All-in-One VC Redist Package and install all versions.
❓ Need More Help?
Visit our FAQ page for solutions to frequently asked questions and common issues.
System Requirements
- OS: Windows 10
- Storage: 600 MB available space
- Additional Notes: Turn down “Render Scale” in settings if framerate is low
Screenshots
